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Prilosec OTC (equivalent to Omeprazole 20mg) has the longest history of safe and effective consumer use of any PPI.

That’s why 30 million Americans± used Prilosec OTC® to treat their frequent heartburn. It works. With one pill each morning, Prilosec OTC® blocks acid so you don’t get heartburn in the first place.

Prilosec OTC tablets are indicated for the treatment of frequent heartburn, which is heartburn that occurs two or more days a week. The label for Prilosec OTC gives specific information for appropriate use to treat frequent heartburn.

Drug Facts

Active Ingredient (in each tablet): Omeprazole delayed-release tablet 20 mg (equivalent to 20.6 mg omeprazole magnesium).

Purpose: Acid reducer


Treats frequent heartburn (occurs 2 or more days a week)
Not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect

Allergy alert: Do not use if you are allergic to omeprazole

Do not use if you have:

trouble or pain swallowing food, vomiting with blood, or bloody or black stools
heartburn with lightheadedness, sweating or dizziness
chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadedness
frequent chest pain
These may be signs of a serious condition. See your doctor.
Ask a doctor before use if you have:

had heartburn over 3 months. This may be a sign of a more serious condition.
frequent wheezing, particularly with heartburn
unexplained weight loss
nausea or vomiting
stomach pain
Ask a doctor or pharmacist before use if you are taking:

warfarin, clopidogrel, or cilostazol (blood-thinning medicines)
prescription antifungal or anti-yeast medicines
diazepam (anxiety medicine)
digoxin (heart medicine)
tacrolimus or mycophenolate mofetil (immune system medicine)
prescription antiretrovirals (medicines for HIV infection)
methotrexate (arthritis medicine)
Stop use and ask a doctor if:

Your heartburn continues or worsens
You need to take this product for more than 14 days
You need to take more than 1 course of treatment every 4 months
You get diarrhea
If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.


For adults 18 years of age and older
This product is to be used once a day (every 24 hours), every day for 14 days
It may take 1 to 4 days for full effect; some people get complete relief of symptoms within 24 hours
14-Day Course of Treatment:

Swallow 1 tablet with a glass of water before eating in the morning
Take every day for 14 days
Do not take more than 1 tablet a day
Do not use for more than 14 days unless directed by your doctor
Swallow whole. Do not chew, crush, or suck tablets.
Repeat 14-Day Courses (if needed):

You may repeat a 14-day course every 4 months
Do not take for more than 14 days or more often than every 4 months unless directed by a doctor
Children under 18 years of age: ask a doctor. Heartburn in children may sometimes be caused by a serious condition.
Other Information:

Read the directions and warnings before use.
Keep the carton. It contains important information.
Store at 20-25°C (68-77°F) and protect from moisture.